Mn(II), Fe(III) and Ni (II) Complexes of Mixed Citric acid - Sulphamethoxazole: Synthesis, Characterization and Antibacterial activity

Abstract Three mixed ligand complexes of sulphamethoxazole and citric acid have been synthesized using Mn(II), Fe(III) Ni(II) chlorides. The were characterized by elemental analysis, melting point, conductivity test, magnetic measurement, UV-Visible infrared spectroscopy. spectra data revealed that the ligands act as bidentate, in which coordinate through C=O carboxyl oxygen hydroxyl groups, while coordinates nitrogen atom primary amine group O=S=O sulphonyl group. result analysis was consistent with proposed pattern for complexes, point determination confirmed compounds pure. Antibacterial activity metal screening against five strain bacteria microorganism g(+) Pseudomonas aeruginosa , Eschericia coli Klebsiella pneumonia Staphylococcus aureus Candida Muller Hinton diffusion method. showed overall zone inhibition bacterial isolate follows an increasing order priority Fe(III)˃ Ni(II)˃ Mn(II) complexes.